Moises Caicedo put the hosts ahead with a 40th-minute strike at La Casa Blanca in Quito, more than 2,800m above sea level.
Flamengo had never before lost a Copa Libertadores match by a five-goal margin. Previously, their worst showing in South America's premier club competition was a 5-1 capitulation to Gremio in 1984. Thursday's result was also the heaviest defeat by defending Copa Libertadores champions.
Stage One will be played across two blocks of eight days: September 13-20 and September 28-October 5. Enditem
ZAGREB, Sept. 14 (Xinhua) -- Olympic champion Ryan Crouser of the United States set a meeting record to win the men's shot put at the World Athletics Continental Tour Gold meeting here on Monday.
The Pole spoke about his side's determination to repeat last season's success. "We did something big, but to go on successfully means forgetting about the past," said Poland's captain.
Once again, Leeds would not be cowed, and the Yorkshire outfit had the effrontery to level the scores again ten minutes later, after a poor clearance from Van Dijk allowed Patrick Bamford to fire past goalkeeper Alisson.
The Changchun team went ahead in the ninth minute with a header from Tan Long.
Shenhua took the upper hand after Yang Xu converted a penalty on 47 minutes from Lu Lin's trip on Peng Xinli but R&F leveled in the 79th minute as Zhang Gong flicked in a cross from Chen Zhizhao.
After the restart, Dortmund started where they left off and controlled proceedings.
Top seeds Novak Djokovic and defending champion Rafael Nadal, who have first round byes, will begin their campaigns on Wednesday.
Getafe's Matchday 1 fixture against Real Madrid was pushed back to a later date due to Real Madrid's European commitments in the summer and Osasuna may feel that after beating Cadiz last week they have a competitive edge against Pepe Bordalas' always tough-to-beat side.