Despite a difficult day, Hamilton retains the lead in the drivers' championship with 205 points, though Bottas has closed the gap and now sits second with 161 points, with Verstappen third on 128 points.
With the result, Hoffenheim capture the top spot with two wins from two games whereas Bayern Munich slip to the 7th position after suffering their first loss in 2020.
The next stage will begin with a two-legged knockout round from October 16. Enditem
Badosa advanced after beating 2018 finalist Sloane Stephens of the United States 6-4, 4-6, 6-2.
However, the wheels came off on Sunday as they crashed to a 6-1 defeat away to Atletico Madrid, who tore Granada's usually solid defense apart time after time.
The hosts did not stop, and created another amazing run, this time 14-0, on the way to a 44-33 lead in the 17th minute and 49-41 at half-time.
The defeat again highlights doubts about Manchester City's defense as they were taken apart by Leicester even though Riyad Mahrez put Guardiola's men ahead in just the fourth minute.
Roberto Lopez sealed the win in the 94th minute with a powerful shot into the corner after another assist from the impressive Merino.
Valladolid and Celta drew 1-1 with Sergi Guardiola's 66th minute penalty cancelling out Iago Aspas' 44th minute strike for Celta.
PARIS, Sept. 26 (Xinhua) -- World No. 1 Novak Djokovic on Saturday discussed his disqualification from this month's US Open and vowed not to make such a mistake again.
Williams injured her Achilles tendon during her semifinal loss to Victoria Azarenka at the US Open earlier this month.